Cardioprotective effect of the PPAR ligand 1 tetradecylthioacetic acid in type 2 diabetic mice
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چکیده
tetradecylthioacetic acid in type 2 diabetic mice 2 3 Ahmed M. Khalid, Anne Dragøy Hafstad, Terje S. Larsen, David L. Severson, Neoma 4 Boardman, Martin Hagve, Rolf K. Berge and Ellen Aasum 5 6 (Ahmed M. Khalid and Anne D. Hafstad have made equal contributions to this paper) 7 1 Cardiovascular Research Group, Department of Medical Biology, Faculty of Health 8 Sciences, University of Tromsø, Norway 9 2 Department of Physiology and Pharmacology, Faculty of Medicine, University of 10 Calgary, Calgary, Alberta, T2N 4N1, Canada 11 3 The Lipid Research Group, Institute of Medicine, University of Bergen, Norway 12 13 14 Running title: Protection of the diabetic heart 15 16 17 18 19 Correspondence to: 20 Ellen Aasum 21 Cardiovascular Research Group, 22 Department of Medical Biology, 23 Faculty of Health Sciences 24 University of Tromsø 25 N-9037 Tromsø, Norway. 26 27 Phone: +47 77 64 67 56 28 Fax: +47 77 64 54 40 29 email: [email protected] 30 31 Articles in PresS. Am J Physiol Heart Circ Physiol (March 18, 2011). doi:10.1152/ajpheart.00357.2010
منابع مشابه
Cardioprotective effect of the PPAR ligand tetradecylthioacetic acid in type 2 diabetic mice.
Tetradecylthioacetic acid (TTA) is a novel peroxisome proliferator-activated receptor (PPAR) ligand with marked hypolipidemic and insulin-sensitizing effects in obese models. TTA has recently been shown to attenuate dyslipidemia in patients with type 2 diabetes, corroborating the potential for TTA in antidiabetic therapy. In a recent study on normal mice, we showed that TTA increased myocardial...
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تاریخ انتشار 2011